Since 53BP1, like E6 and E7, is a binding partner of the central DNA binding domain of p53, pRb, CBP/p300 and p107 pRb-like proteins, with whom it cooperates in tumor suppression [35–37, 71–73], we hypothesized that E6 and E7 could bind to this DNA damage detector. Here, TP53BP1 is linked to neoplasm.