Meanwhile, we found the ability of tumor cell invasion increased dramatically after treated with Akt1 specific siRNA in MCF-7 and MDA-MB-231 breast cancer cells using transwell assay with Matrigel, while XAV-939 could reverse the enhanced invasive ability of breast cancer cells induced by Akt1 knockdown (Fig. 1g-h). Here, AKT1 is linked to breast carcinoma.