Multivariate logistic regression analysis calculated the probability for nonrecovery based on the endostatin–clinical risk prediction model: the probability for nonrecovery = 1 / (1 + e–z), z = − 4.029 + 0.022 × endostatin + 0.280 × SOFA score – 0.937 × AKI stage 1 + 1.850 × AKI stage 3. The gene discussed is COL18A1; the disease is acute kidney injury.