Although we could not exclude the possibility that various cytokines and growth factors abundantly contained in cAT-MSC CM (other than FGF1) could affect the alterations in expression levels, it is worth mentioning that this study is the first work that revealed FGF1 as a specific mediator of insulin-sensitizing effects of cAT-MSC CM in DM. The gene discussed is FGF1; the disease is diabetes mellitus.