Whilst we have previously shown that Kpnβ1 inhibition, genetically or pharmacologically, resulted in an induction of cervical cancer cell death and the appearance of mitotic defects [9, 10, 25], others have reported that exogenously expressed Kpnβ1 induced mitotic abnormalities, resulting in genomic instability [7, 8]. The gene discussed is KPNB1; the disease is cervical carcinoma.