Taken together, in our study, p53 and p21 enhance and protect cervical cancer cells from Cisplatin-induced cell death, respectively, thus the higher p53 and lower p21 in the Kpnβ1-EGFP-overexpressing cells likely contributes, at least in part, to the increased sensitivity of these cells to Cisplatin. This evidence concerns the gene KPNB1 and cervical cancer.