In addition, outcomes in certain genetic sub-types e.g., ABC (activated B-cell) versus GC (germinal center) DLBCL are inferior [4, 5], and patients with double- (or triple-) hit lymphomas displaying increased expression of BCL-2, BCL-6, and/or c-Myc do particularly poorly [6]. Here, BCL2 is linked to diffuse large B-cell lymphoma.