This approach reflects uncertainty regarding the progeria phenotype at the single cell level: although it is known that progeria is caused by the expression of the lamin A-mutant progerin, it remains unknown how progerin expression changes other features, such as blebbed nuclear envelope, DNA damage accumulation, and mislocalized lamin B1 expression at the single-cell level, and how these different features correlate with one another. The gene discussed is LMNA; the disease is progeroid syndrome.