MACROH2A1 and hepatocellular carcinoma: Although the existence of CSCs in HCC is still a matter of some debate, Re et al. showed that loss of macroH2A1 (a variant of the histone H2A and an epigenetic regulator of stem cell function) in HCC led to CSC-like features such as chemoresistance and tumor-forming capacity through metabolic changes [82].