EGFR and non-small cell lung carcinoma: The phase I/II clinical trials of osimertinib (AURA 1/AURA 2 trials) involving EGFR mutation-positive patients with NSCLC who became resistant to EGFR-TKI demonstrated that the median PFS was 9.6 months (95% CI, 8.3 to not reached), the overall response rate (ORR) of negative cases was 21% (95% CI, 12 to 34), and the median PFS was 2.8 months (95% CI, 2.1 to 4.3) [29].