Furthermore, a randomized phase IIb trial comparing afatinib and gefitinib in patients with NSCLC harboring an active EGFR mutation (LUX-Lung 7 trial) revealed superiority of afatinib regarding progression-free survival (PFS) (HR, 0.73; 95% CI, 0.57 to 0.95; p = 0.0073; 11.0 vs. 10.9 months, respectively) [22]. Here, EGFR is linked to non-small cell lung carcinoma.