HOTAIR and cancer: Although the function of majority of lncRNAs are unknown, the mode of action of a few like X inactive specific transcript (XIST, functions in X chromosome inactivation, chromatin modification etc.)[7,13,14], HOX transcript antisense RNA (HOTAIR, functions in positional identity, regulate gene expression in trans and is associated with a variety of cancers) [15,16,17] and metastasis associated lung adenocarcinoma transcript 1 (MALAT1, functions in nuclear structure organization and is associated with a variety of cancers etc.)[18] are well characterized.