AKT1 and type 2 diabetes mellitus: It is possible that the downregulation of miR-126 counteracts angiogenesis, since miR-126 was also found with a reduced expression in endothelial progenitor cells obtained from T2D patients, correlating with a decreased proliferation, migration, and increased induction of apoptosis, through the disinhibition of SPRED1, which in its turn inhibits the Ras/ERK/VEGF and PI3K/Akt/eNOS signal pathways [147].