INSR and acute kidney injury: In the cited study [33], the finding that, in isolated renal tubules, I-R induces ferroptosis but not necroptosis, which however is prevalent in the pathogenesis of I-R-induced AKI in vivo [32], may indicate that ferroptosis of RPTECs may be the initial insult, and the subsequent release of danger-associated molecular patterns and recruitment of immune cells trigger a second wave of cell death through necroptosis.