The antagonism of TRPM8 by N-(3-aminopropyl)-2-{[(3-methylphenyl)methyl]oxy}-N-(2-thienylmethyl) benzamide (AMTB) has also been considered for DED treatment, since evaporative cooling and hyperosmotic stimuli trigger dry eye pain as well as blinking [40]. This evidence concerns the gene TRPM8 and Keratoconjunctivitis sicca.