A study on the role of CXCR4 in EOC metastases showed that downregulation of CXCR4 by short hairpin RNA (shRNA) resulted in a robust reduction of the circulating tumor cells, suggesting a possible role of the stromal cell-derived factor 1 (SDF1)/CXCR4 axis in the hematogenous route of dissemination [112]. Here, CXCL12 is linked to neoplasm.