Supplemental Table S1 lists 70 Class I mutations including 63 phosphorylation, 6 acetylation and 1 ubiquitylation sites. Table 1 summarizes the ten Class I PTMVars that have the greatest number of associated HTP but no LTP records. At the top of the list is phosphoTyr62 SHP-2: Tyr62, when mutated, is associated with Juvenile Myelomonocytic Leukemia (17) and Noonan Syndrome 1 (18). Five of these variants overlap with PTM sites. One, phospho-Y62, has been detected in 2,090 mass spectrometry analyses (Table 2) including 800 patient tumors: 36% are lung, 13% liver and 8% ovarian cancers. The gene discussed is PTPN11; the disease is Noonan syndrome.