Moreover, among our 259 control patients with SCLC without neurological symptoms, there were 11 patients who had raised VGCC antibodies, in the absence of LEMS: positivity for SOX2 antibodies in these patients was low (3/11, 27%), similar to the levels of SOX2 positivity seen in the control SCLC population as a whole. Here, SOX2 is linked to small cell lung carcinoma.