Median SOX2 antibody levels (at the highest concentration of antigen analysed, 160 nM) were statistically higher in LEMS-SCLC (0.72 optical density, OD) than SCLC without PNS (0.10 OD) (P < .0001), OMS-SCLC (0.33 OD) (P = .05), SSN-SCLC (0.38 OD) (P = .044) or LE-PCD (0.32 OD) (P = .03),but more similar to PCD-SCLC (0.62 OD) (P = .48), the last of which almost all had associated LEMS (Fig. 2). The gene discussed is SOX2; the disease is Lambert-Eaton myasthenic syndrome.