The level of SOX2 positivity in patients with LEMS-SCLC (37/61, 61%) was higher than that seen in all other paraneoplastic disorders associated with SCLC (OMS-SCLC 3/6, 50%; LE-SCLC 5/12, 42%; SSN-SCLC 16/32, 50%): although similar levels of SOX2 positivity was found in PCD-SCLC (10/17, 59%), where all of these patients also had LEMS. The gene discussed is SOX2; the disease is paraneoplastic neurologic syndrome.