SERPINH1 and endothelial dysfunction: SERPINH1 (rs590121 lead SNP) is predicted to increase risk of hemorrhage; DDX59-CAMSAP2 (rs1867624) may be involved abnormal vascular development; PECAM1 (rs1867624) may regulate vascular inflammation and endothelial dysfunction; and LMOD1 (rs2820315) is implicated in SMC differentiation[4].