In literature, there is no similar pathology than what we observe in Angpt4-/- mice (congenital decrease in vein diameter, venous SMC abnormality, diminished vein flow, but no inflammation or leakage), making direct comparison to the better characterized retinal pathologies (such as diabetic retinopathy and retinal vein occlusion) difficult. This evidence concerns the gene ANGPT4 and diabetic retinopathy.