CD8+ T cell‐depleted mice exhibited reduced infarct volume compared to non‐depleted (IgG‐only injected) ischemic mice (22.98 ± 4.00 vs 29.11 ± 2.92, P < 0.01) 7 days after stroke (Figure 6B) and protected against the damage to white fiber bundles in the striatum and external capsule (Figure 6B, C). The gene discussed is CD8A; the disease is Stroke.