In addition, decreasing infiltration of CD8+ T cells in the central nervous system via blocking α4 integrin with myelin oligodendrocyte glycoprotein (MOG33‐35) protects the white matter damage in the EAE model.42 Similarly, blocking the activation and infiltration of CD8+ T cells may reverse the demyelinating injuries during the late phase of ischemic stroke recovery. This evidence concerns the gene CD8A and ischemic stroke.