EGFL6 is an epidermal growth factor‐like protein, it is well known that it plays a series of roles in endothelial cell behaviors and angiogenesis of.19, 20 Recently, there are some reports prove that EGFL6 involved in the progression of human cancer, such as ovarian cancer,21 breast cancer,22 meningioma.9 However, the relationship between EGFL6 and NPC has not been elucidated clearly. This evidence concerns the gene EGFL6 and breast cancer.