The increased Bax/Bcl‐2 ratio is responsible for the apoptosis of S180 tumour cells in the mouse model.33 Zhang et al showed that WPS could inhibit the growth of human breast carcinoma MCF‐7 cells by inducing G1 arrest of the cell cycle and by elevating the Bax/Bcl‐2 ratio.39 This evidence concerns the gene BAX and breast carcinoma.