ROCK1 and Hyperglycemia: ROCK1 has been demonstrated to participate in Drp1 mediated‐mitochondrial fission under hyperglycaemia conditions.26 In the present study, we further confirmed that high glucose promotes the protein expression of ROCK1 compared with the normal group (P < 0.001), and VLD inhibited that of ROCK1 compared with high glucose group though no significant effects were found (P = 0.107) (Figure S3A).