Although GW5074 could impair clonogenic and tumorigenic capacity of CRC cells by its inhibitory effect on c‐Raf kinase activity (Borovski et al., 2017), our studies demonstrated it could significantly reduce the expression level of endogenous SIRT5 and blocked autophagic flux and tumour cell proliferation via SIRT5/LDHB axis. Here, LDHB is linked to neoplasm.