This overexpression seems to be present also in subsets of immune cells, including B and T cells, macrophages and dendritic cells.11 Several studies demonstrated a strong correlation between PD‐L1 expression on various tumour cells and a worse patients' prognosis.15, 16, 17, 18 Many studies have also been conducted to discover a possible role of the PD‐1/PD‐L1 axis in the biology of OSCC.19, 20 Its potential clinical and pathological implication has also been investigated providing, however, non‐homogeneous conclusions. The gene discussed is PDCD1; the disease is neoplasm.