These data are important for the concept of precise medicine, according also to the evidence that microenvironment has an important role in PD‐L1 expression and tumour behaviour, as showed in other kinds of cancer74 and in OSCC.33, 37, 40 According to these statements, future research should focus on the validation and standardization of all steps, from biopsy, IHC assay and tumour microenvironment evaluation for the selection of patients, who can undergo anti‐PD‐L1 therapy. Here, CD274 is linked to neoplasm.