In fact, such marker has demonstrated to be an independent prognostic factor in different cancer types, including NSCLC,60 renal cell carcinoma61 and breast cancer.62 However, there are conflicting evidences in relation to the prognostic value of PD‐L1 in different types of cancer.63, 64, 65 Results of this study failed to reveal a correlation between the expression of PD‐L1 in tissues and a poor prognostic of OSCC patients. This evidence concerns the gene CD274 and breast cancer.