A role for ATG4B in cancer has been proposed, including chronic myeloid leukemia (Rothe et al., 2014), osteosarcoma (Akin et al., 2014), colorectal cancer (Liu et al., 2014), prostate cancer (Mouratidis et al., 2014), breast cancer (Bortnik et al., 2016) and pancreatic adenocarcinoma (Yang et al., 2018). This evidence concerns the gene ATG4B and chronic myelogenous leukemia, BCR-ABL1 positive.