On this basis, to assess the effect of the local/systemic delivery of PTX3 protein on fibrosarcoma growth, wild type MC17-51 cells were injected in syngeneic wild type (C57BL/6) and transgenic TgN(Tie2-hPTX3) mice that overexpress human PTX3 under the endothelial specific Tie2 promoter (17). Here, PTX3 is linked to fibrosarcoma.