The FGF/FGFR system is a key player in the tumor/microenvironment interplay (5, 31) and its aberrant activation consequent to FGF2 overexpression may trigger fibrosarcoma progression by facilitating fibroblast transformation and increasing fibrosarcoma aggressiveness, neovascularization and metastatic potential (9, 11). The gene discussed is FGF2; the disease is fibrosarcoma.