PTX3 and fibrosarcoma: In keeping with the inhibitory activity exerted by PTX3 on fibrosarcoma cells, and with the relevance of the FGF/FGFR system in fibrosarcoma biology, treatment with the PTX3-derived FGF-trap NSC12 causes a significant inhibition of the tumorigenic potential of HT-1080 cells in vitro and in vivo, paralleled by a decrease of FGFR activation and signaling in these cells.