The minor alleles: TOMM40’523-L,’650-G and APOC1’638-G were shown to be significantly overrepresented in AD group as compared to controls (‘523 L vs. S+VL: OR=5.61, 95% CI: 2.87-10.9, p<0.0001; ‘650 G vs. A: OR=6.12, 95% CI: 2.98-12.6, p<0.0001; and ‘638 G vs. A: OR=5.66, 95% CI: 3.07-10.4, p<0.0001), and were more specific than APOE E4 (OR=5.14, 95% CI: 2.68-9.85, p<0.0001). Here, APOE is linked to Alzheimer disease.