In turn, the AD patients with aggregation of minor alleles: TOMM40’523 L/L, ‘650 G/G, and APOC1’638 G/G exhibited 13.7±6.9 years earlier AOO than those with major variants: TOMM40 VL/VL, A/A and APOC1 A/A (p<0.01, unpaired T test). The gene discussed is APOC1; the disease is Alzheimer disease.