The concentration of homocysteine (Hcy), glutathione (GSH), 8-oxo-2’-deoxyguanosine (8-oxo2dG) and 8-oxoguanine DNA glycosylase (OGG1) in plasma of Alzheimer’s disease (AD) patients, related (RC) and unrelated controls (UC) stratified according to TOMM40’523 genotype. This evidence concerns the gene OGG1 and early-onset autosomal dominant Alzheimer disease.