Similarly, researchers have shown that Natural Killer T (NKT) cells might play a major role in tumor development in a genetic background susceptible to carcinogenesis (20), as it has been observed that loss of type 1 NKT cells enhances tumor development in p53+/− mice and secondly, NKT cells protect against B-cell lymphoma development in mice (20, 21). The gene discussed is TNFRSF10B; the disease is neoplasm.