IL6 and neoplasm: For example, miRNAs in tumor-derived microvesicles (MVs)/exosomes such as miR-24-3p, miR-891a, miR-106a-5p, miR-20a-5p, and miR-1908, have been found to impair T cell function by inhibiting Th1 and Th17 differentiation; downregulating the MAPK pathway; affecting the secretion of cytokines such as IL-1β, IL-6, IL-10, IFN-γ, IL-2, and IL-17, and reducing the antitumor effect (22).