Among the IPEX-like cohort, patients with mutations in genes related to Treg function (i.e., CD25, STAT5b, STAT3 and STAT1 GOF, LRBA, CTLA4) are affected by a clinical phenotype strongly resembling IPEX. Here, IL2RA is linked to immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.