SKIC3 and immune system disorder: The tetratricopeptide repeat domain 37 (TTC37) gene, if mutated, causes Trichohepatoenteric Syndrome (THES), a rare autosomal recessive disorder characterized by growth restriction, severe infantile diarrhea, trichorrhexis nodosa-like hair morphology, hepatopathy, facial dysmorphism, and immunodeficiency (100).