The activated macrophage cells bearing bacterial pathogen challenges normally produce and release IL-12 for activation of Th1 cells and further induces INF-γ, TNF-α, and IL-12 production (Romagnani, 1999; Dong and Flavell, 2001; Bassaganya-Riera et al., 2003; Kidd, 2003), which explained the significantly elevated expressions of TNF-α and IL-12 genes with ST infections. The gene discussed is TNF; the disease is infection.