In another current study, SUMOylated centrosomal P4.1-associated protein (CPAP) was reported to be implicated in IKK-mediated NF-κB activation, leading to enhanced HBx-induced NF-κB signaling in HBV-related HCC (Yang et al., 2013). The gene discussed is NFKB1; the disease is hepatocellular carcinoma.