For example, HBx can directly interact with amplified in breast cancer 1 (AIB1), a crucial enhancer required for the activation of specific transcription factors, such as NF-kB and AP-1, preventing interactions between Fbw7α and AIB1 and inhibiting the Fbw7α-mediated ubiquitination and degradation of AIB1, leading to HCC cell invasiveness (Liu et al., 2012). Here, NCOA3 is linked to hepatocellular carcinoma.