Notably, AAMφ development is dependent on IL-4/IL-13 stimulation, which activates the transcription factor STAT-6, and STAT-6-deficient mice are more prone to obesity, oxidative stress in their AT and susceptibility to T2D development, which, in turn, is associated with the absence of AAMφs (Ricardo-Gonzalez et al., 2010). This evidence concerns the gene STAT6 and obesity due to melanocortin 4 receptor deficiency.