In addition, another group previously demonstrated that the antifibrotic agent tranilast, and its derivatives FT011 and FT23, act to oppose TGFβ-mediated fibrosis in a streptozotocin-induced transgenic (mRen-2)27 hypertensive rat model of DCM (Martin et al., 2005; Kelly et al., 2007; Tan et al., 2012; Zhang et al., 2012). The gene discussed is TGFB1; the disease is familial dilated cardiomyopathy.