In addition, ILG mimics the effects of PGC-1α-mediated mitochondrial biogenesis, calorie restriction, 5′ AMP-activated protein kinase (AMPK)–mediated autophagy and Forkhead box O3a (FOXO3a) mediated stress resistance to counteract experimental diabetic neuropathy (Yerra et al., 2017). This evidence concerns the gene FOXO3 and diabetic neuropathy.