Li et al. (2008) have shown that in rats, Nestin+ neurons within the MS/dB decline with age, and that rat that displayed age-related memory impairment on Morris water maze had the lowest number of Nestin+ neurons. Furthermore, Nestin+ neurons in aged rats show reduced complexity with respect to dendritic arborization and dendritic length (Li et al., 2008). Here, NES is linked to memory impairment.