Because we observed avocatin B-induced upregulation of ATF4 in AML cells in the presence but not in the absence of BM adipocytes, we performed ATF4 knockdown experiments and examined the cytotoxic efficacy of avocatin B with/without AraC combination in the presence of BM adipocytes (Fig. 4D, Supplementary Fig. S8). Here, ATF4 is linked to acute myeloid leukemia.