In AML cells co-cultured with BM adipocytes, avocatin B significantly increased expression of transcription factor ATF4, the master regulator of the integrated stress response, and its downstream target genes, including ASNS. Ye et al. demonstrated that activation of the ATF4-ASNS pathway supports tumor cell survival under stress conditions, including nutrient deprivation30. This evidence concerns the gene ASNS and acute myeloid leukemia.