To study the antitumor effects of the EGFR-targeted 4-1BB-agonistic trimerbody in immune competent mice, we used murine CT26 colorectal carcinoma (H-2d) cells infected with retrovirus encoding human EGFR (CT26hEGFR) (Supplementary Figure 13a). The gene discussed is EGFR; the disease is colorectal carcinoma.