In order to understand the antitumor immune response generated with 4-1BB antibodies, tumors from 3H3 IgG- and 1D8N/CEGa1-treated mice and control mice were extracted 2 days after receiving the third i.p dose (day 13 after tumor inoculation) (Supplementary Figure 15) for immunohistochemistry to quantify tumor-infiltrating CD8 + T lymphocytes (TILs). The gene discussed is CD8A; the disease is neoplasm.