3H3 IgG- and 1D8N/CEGa1-cured mice (P = 0.0027 and P = 0.0067, respectively), but not age-matched naive mice, were resistant to a rechallenge with CT26mock tumor cells (Fig. 5c and Supplementary Figure 14), showing that the trimerbody-mediated EGFR-targeted 4-1BB costimulation can induce long-term protective immunological memory against CT26 tumors that do not express hEGFR. This evidence concerns the gene EGFR and neoplasm.