While amlodipine or the combination of hydralazine plus hydrochlorotiazide also prevented AngII-induced aortic rupture in conditional Rcan1−/− mice, norepinephrine infusion of these mice did not induce aortic rupture, suggesting that AngII-induced hypertension is necessary but not sufficient to elicit aortic rupture. Here, AGT is linked to Hypertension.