Therefore, we compared Beclin1, ATG5, ATG9, L3CB, p62, and LAMP-2, levels between patients with PD and normal controls, and investigated their correlations with clinical severity, quantitative dopamine transporter imaging data, and conventional CSF biomarkers in patients with PD to investigate the roles of various ATG proteins as biomarkers of the pathogenic process in patients with PD. The gene discussed is BECN1; the disease is Parkinson disease.