Additionally, the study by Ong et al. [35] revealed that the GGT haplotype (−605G, 143G, and 3836T) was associated with higher plasma level of U-II, insulin and higher homeostasis model assessment of insulin resistance index and β-cell function, suggesting the possible role of UII 143G>A (rs228648) polymorphism in the glycemic control via the regulation of plasma UII levels and insulin resistance. Here, INS is linked to Insulin resistance.