MTHFR and keratosis pilaris: But we are of opinion that variants (677CT, 677TT and 1298 AC, 1298CC) of MTHFR gene may have association with poor seizure control during carbamazepine therapy in epileptic Pakhtun patients of KP due to indirect metabolic effect through deficiency of vitamin B6 that helps in synthesis of inhibitory neurotransmitters.