Losma treatment also reduced, while SCH treatment blocked, hiPSC-EC differentiation in the presence of U-46619, which activated p38MAPK and ERK1/2 [35, 36] and increased the magnitude and duration of the expression of endothelial transcription factors such as Etv2, Gata-2, and Tal-1. The gene discussed is MAPK3; the disease is spindle cell hemangioma.