Both treatments during stage 2 led to declines in CD31 mRNA levels, and expression of the endothelial transcription factors Evt2, Gata-2, and Tal-1 were either reduced (Evt2, Gata-2) or delayed (Tal-1) in Losma-treated cells; the expression of all three factors declined in response to SCH treatment. This evidence concerns the gene PLEKHB2 and spindle cell hemangioma.