ESR1 and thyroid gland carcinoma: The highest class discriminability score for this classification is found in discriminating thyroid carcinoma protein profiles for classes 0 and 1 (sdis = − 2.07; p = 0.0; srand = − 1.3e−4; characteristic protein profiles: ER-alpha, PR, GATA3, Bcl-2, and INPP4B increased for class 0—increased for class 4: Cyclin_B1 and ASNS).