For endometrial carcinoma, protein profiles between class 2 and class 4 differ for ER-alpha, Akt_pS473, Akt_pT308, E-Cadherin, ER-alpha_pS118, Claudin-7, and CD49b (increased in class 2), and p53, Cyclin_B1, Cyclin_E1, and IGFBP2 (increased in class 4). The gene discussed is IGFBP2; the disease is endometrial carcinoma.