Similar to previous results in AD patients (Fig. 1a, b), GRP78 and CHOP levels were significantly increased in APP/PS1 mice, as compared to WT and KCa3.1−/− mice (p < 0.05, Fig. 4a–c), while the expression levels of GRP78 and CHOP were significantly decreased in KCa3.1−/−/APP/PS1 mice, as compared to APP/PS1 mice (p < 0.05, Fig. 4a–c). This evidence concerns the gene PSEN1 and Alzheimer disease.