The discrepancy between secreted cytokine increases in VZV-infected cells and the undetectable, unchanged, or decreased transcripts for IL-10, IL-1β, IL-12p70, and IL-6 may be due to a negative feedback loop, transcripts below the level of quantitation on qPCR, or the fact that secreted cytokines represented cumulative cytokine production over the 3 days of infection, whereas transcripts only represented a single point. Here, IL6 is linked to infection.