LDLR and atherosclerosis: Considering the cellular infiltrates, it is worth mentioning that the predominance of M4 macrophages in diseases such as atherosclerosis demonstrates that cells change their behavior favoring the appearance of foam cells and the development of an oxidative stress response inducing chemokine production and monocyte recruitment, thereby facilitating the accumulation of macrophages that express large amounts of LDL receptors [33, 34].