Based on our transcriptome analysis, we focused on the five most differentially expressed genes: PHD3, FABP7, CAIX, NDUFA4L2, and MCT4. All the genes have been regarded as working downstream of HIF in relation to hypoxia, metabolism, and pH regulation in cancer, which are supposed to induce the Warburg effect [21]. This evidence concerns the gene EGLN3 and cancer.