In all patients with sepsis, serum tenascin-C was significantly positively correlated with SOFA score (P = 0.011), serum creatinine (P = 0.006), CRP (P = 0.001), IL-6 (P < 0.001) and TNF-α (P = 0.026) (Table 2). The gene discussed is CRP; the disease is Sepsis.