α-Klotho concentrations increased from 554 (IQR 388–659) to 591 (IQR 358–742) pg/mL (P = 0.19) and from 547 (IQR 421–711) pg/mL to 654 (IQR 538–754) pg/mL (P = 0.13) in the CKD and the healthy subgroup respectively. This evidence concerns the gene KL and chronic kidney disease.