T cells expressing the CD4 co-receptor are vital for mounting an adaptive immune response [7], and are loosely split into two major groups: (i) so-called ‘helper’ T cells, required for antibody production and subsequent affinity maturation of the response, in addition to immunological memory [7–11], and (ii) ‘regulatory’ T cells that suppress immune responses, preventing autoimmunity [12, 13]. Here, CD4 is linked to Autoimmunity.